p22(phox) prevents the oxidation of SERCA2a and stabilizes it in the heart

Nakada Y, Titus AS, Mizushima W, Yang Y, Zhai P, Tian Y, Oka S, Kashihara T, Fefelova N, Pamarthi SH, Liu T, Li H, Xie LH, Takayama K, Ikeda S, Matsushita M, Huang CY, Hsu CP, Onoue K, Saito Y and Sadoshima J. p22(phox) prevents the oxidation of SERCA2a and stabilizes it in the heart. Nat Cardiovasc Res. 2025;4:1187–1205.PMC12436179

Potential Molecular Mechanism of FNDC4 Protection Against Aging in the Heart

Matsushita M and Sadoshima J. Potential Molecular Mechanism of FNDC4 Protection Against Aging in the Heart. JACC Basic Transl Sci. 2025;10:101304.PMC12434195

Recent progress regarding the role of autophagy in cardiac disease

Maejima Y, Titus AS, Zablocki D and Sadoshima J. Recent progress regarding the role of autophagy in cardiac disease. Cardiovasc Res. 2025;121:2299–2317

Role of Vascular Niche in Cardiac Aging

Ikeda S, Sung EA and Sadoshima J. Role of Vascular Niche in Cardiac Aging. Circ Res. 2025;137:1368–1370.PMC12712850

On the utility of immobilized phenylarsine oxide in the study of redox sensitive cardiac proteins

Francois AA, Yin X, Oka S, Sadoshima J, Mayr M and Eaton P. On the utility of immobilized phenylarsine oxide in the study of redox sensitive cardiac proteins. Sci Rep. 2025;15:15554.PMC12049532

Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction

Abdellatif M, Vasques-Novoa F, Trummer-Herbst V, Durand S, Koser F, Islam M, Nah J, Sung EA, Feng R, Aprahamian F, Prokesch A, Zardoya-Laguardia P, Sadoshima J, Diwan A, Linke WA, Ferreira JP, Kroemer G and Sedej S. Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction. Eur Heart J. 2025;46:1863–1866.PMC12075933

NAD+ repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling

Abdellatif M, Vasques-Novoa F, Ferreira JP, Sadoshima J, Diwan A, Linke WA, Kroemer G and Sedej S. NAD(+) repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling. Autophagy. 2025;21:2296–2298.PMC12459361

An optimized plasmalogen modulating dietary supplement provides greater protection in a male than female mouse model of dilated cardiomyopathy

Belkin TG, Masterman EI, Yildiz GS, Kiriazis H, Mellett NA, Cross J, Grigolon K, Dogra A, Donner D, Chooi R, Liang A, Kompa AR, Sadoshima J, Edgley AJ, Greening DW, Meikle PJ, Tham YK and McMullen JR. An optimized plasmalogen modulating dietary supplement provides greater protection in a male than female mouse model of dilated cardiomyopathy. J Mol Cell Cardiol Plus. 2025;11:100273.PMC11708127

Macrophages release miRNAs in response to Doxorubicin with a potential role in indirect cardiac damage

Buonaiuto A, Gambardella J, Santulli G, Fiordelisi A, Wang X, Prevete N, Sommella E, Avvisato R, Cerasuolo FA, Altobelli GG, Ciccarelli M, Morisco C, Sadoshima J, Iaccarino G and Sorriento D. Macrophages release miRNAs in response to Doxorubicin with a potential role in indirect cardiac damage. Vascul Pharmacol. 2024;155:107302

Macrophages participate in doxorubicin-induced cardiac damage

Cerasuolo FA, Gambardella J, Santulli G, Fiordelisi A, Wang X, Prevete N, Sommella E, Avvisato R, Buonaiuto A, Altobelli GG, Ciccarelli M, Morisco C, Sadoshima J, Iaccarino G and Sorriento D. Macrophages participate in doxorubicin-induced cardiac damage. Vascul Pharmacol. 2024;155:107309

Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation

Chen YC, Wijekoon S, Matsumoto A, Luo J, Kiriazis H, Masterman E, Yildiz G, Cross J, Parslow AC, Chooi R, Sadoshima J, Greening DW, Weeks KL and McMullen JR. Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation. Clin Sci (Lond). 2024;138:941-962.PMC11292366

Mst1-mediated phosphorylation of FoxO1 and C/EBP-β stimulates cell-protective mechanisms in cardiomyocytes

Maejima Y, Nah J, Aryan Z, Zhai P, Sung EA, Liu T, Takayama K, Moghadami S, Sasano T, Li H and Sadoshima J. Mst1-mediated phosphorylation of FoxO1 and C/EBP-beta stimulates cell-protective mechanisms in cardiomyocytes. Nat Commun. 2024;15:6279.PMC11282193

Editorial commentary: Targeting CLOCK: BMAL1 for treatment of ischemia/reperfusion injury

Sadoshima J. Editorial commentary: Targeting CLOCK: BMAL1 for treatment of ischemia/reperfusion injury. Trends Cardiovasc Med. 2024;34:8-9

Nobiletin, a polymethoxylated flavonoid, regulates cell survival via the nuclear receptor RORα in cardiomyocytes

Shiheido-Watanabe Y and Sadoshima J. Nobiletin, a polymethoxylated flavonoid, regulates cell survival via the nuclear receptor RORalpha in cardiomyocytes. J Cardiovasc Aging. 2024;4.PMC11309434

A transcriptional regulatory mechanism of genes in the tricarboxylic acid cycle in the heart

Veera S, Tang F, Mourad Y, Kim S, Liu T, Li H, Wang Y, Warren JS, Park J, Van C, Sadoshima J and Oka SI. A transcriptional regulatory mechanism of genes in the tricarboxylic acid cycle in the heart. J Biol Chem. 2024;300:107677.PMC11415578

Early impairment in mitochondrial quality check and function precedes the development of cardiac phenotypes in an mouse model of Fabry Disease

Gambardella J, Fiordelisi A, Cerasuolo FA, Buonaiuto A, Avvisato R, Viti A, Sommella E, Campiglia P, D'Argenio V, Prevete N, D'Apice S, Varzideh F, Paolillo R, Perrino C, Riccio E, Pisani A, Bianco A, Sadoshima J, Spinelli L, Santulli G, Sorriento D, Iaccarino G. Early impairment in mitochondrial quality check and function precedes the development of cardiac phenotypes in an mouse model of Fabry Disease. Vascul Pharmacol. 2024 Jun;155:107320. doi: 10.1016/j.vph.2024.107320. PMID: 38985588.

Cardiomyocyte senescence and the potential therapeutic role of senolysis in the heart

Zhai P and Sadoshima J. Cardiomyocyte senescence and the potential therapeutic role of senolysis in the heart. J Cardiovascular Aging. 4:18, 2024. DOI: 10.20517/jca.2024.06.

Suppression of autophagy induces senescence in the heart

Zhai P, Sung EA, Shiheido-Watanabe Y, Takayama K, Tian Y, and Sadoshima J. Suppression of autophagy induces senescence in the heart. Preprint. bioRxiv doi: https://doi.org/10.1101/2024.05.26.595978.

Decoding the impact of the Hippo Pathway on different cell types in heart failure

Hu C, Francisco J, Del Re DP and Sadoshima J. Decoding the Impact of the Hippo Pathway on Different Cell Types in Heart Failure. Circ J. 2024.

Improved mitochondrial function in the heart of sarcolipin-deficient dystrophin and utrophin double knockout mice

Mareedu S, Fefelova N, Galindo CL, Prakash G, Mukai R, Sadoshima J, Xie LH and Babu GJ. Improved mitochondrial function in the heart of sarcolipin-deficient dystrophin and utrophin double knockout mice. JCI Insight. 2024.

International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

Chen X, Tsvetkov AS, Shen HM, Isidoro C, Ktistakis NT, Linkermann A, Koopman WJH, Simon HU, Galluzzi L, Luo S, et al. International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. Autophagy. 2024:1-34

Regulation of Myocardial Glucose Metabolism by YAP/TAZ Signaling

Kashihara T and Sadoshima J. Regulation of myocardial glucose metabolism by YAP/TAZ signaling. J Cardiol. 2024;83:323-329

Metabolic control of regulation of myocardial glucose metabolism by YAP/TAZ signaling

Zimmermann A, Madeo F, Diwan A, Sadoshima J, Sedej S, Kroemer G and Abdellatif M. Metabolic control of mitophagy. Eur J Clin Invest. 2024;54:e14138

384 Vendrov AE, Xiao H, Lozhkin A, Hayami T, Hu G, Brody MJ, Sadoshima J, Zhang YY, Runge MS and Madamanchi NR. Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy. Redox Biol. 2023;67:102937. PMC10598408.

383 Toro CA, De Gasperi R, Aslan A, Johnson N, Siddiq MM, Chow C, Zhao W, Harlow L, Graham Z, Liu XH, Sadoshima J, Iyengar R and Cardozo CP. Muscle-restricted Nox4 knockout partially corrects muscle contractility following spinal cord injury in mice. bioRxiv. 2023. PMC10418279.

382 Tong M, Mukai R, Mareedu S, Zhai P, Oka SI, Huang CY, Hsu CP, Yousufzai FAK, Fritzky L, Mizushima W, Babu GJ and Sadoshima J. Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy. Circ Res. 2023;133:6-21. PMC10330464.

381 Titus AS, Sung EA, Zablocki D and Sadoshima J. Mitophagy for cardioprotection. Basic Res Cardiol. 2023;118:42. PMC10556134.

380 She G, Du JC, Wu W, Pu TT, Zhang Y, Bai RY, Zhang Y, Pang ZD, Wang HF, Ren YJ, Sadoshima J, Deng XL and Du XJ. Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction. Theranostics. 2023;13:560-577. PMC9830444.

379 Schirone L, Vecchio D, Valenti V, Forte M, Relucenti M, Angelini A, Zaglia T, Schiavon S, D'Ambrosio L, Sarto G, Stanzione R, Mangione E, Miglietta S, Di Bona A, Fedrigo M, Ghigo A, Versaci F, Petrozza V, Marchitti S, Rubattu S, et al. MST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation. Cell Mol Life Sci. 2023;80:245. PMC10421787.

378 Sadoshima J. Caveolin-3 Nitration Drives Insulin Resistance in Prediabetic Hearts. Circulation. 2023;147:1180-1182. PMC10091234.

377 Oka SI, Titus AS, Zablocki D and Sadoshima J. Molecular properties and regulation of NAD(+) kinase (NADK). Redox Biol. 2023;59:102561. PMC9763689.

376 Nakamura M, Keller MA, Fefelova N, Zhai P, Liu T, Tian Y, Ikeda S, Del Re DP, Li H, Xie LH and Sadoshima J. Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice. Nat Commun. 2023;14:5805. PMC10509265.

375 Nagarajan N, Oka SI, Nah J, Wu C, Zhai P, Mukai R, Xu X, Kashyap S, Huang CY, Sung EA, Mizushima W, Titus AS, Takayama K, Mourad Y, Francisco J, Liu T, Chen T, Li H and Sadoshima J. Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia. J Clin Invest. 2023;133. PMC9888389.

374 Mukai R and Sadoshima J. Ketone Bodies Preserve Mitochondria Through Epigenetics. JACC Basic Transl Sci. 2023;8:1138-1140. PMC10544105.

373 Maejima Y, Zablocki D, Nah J and Sadoshima J. The role of the Hippo pathway in autophagy in the heart. Cardiovasc Res. 2023;118:3320-3330. PMC10060713.

372 Greatorex S, Kaur S, Xirouchaki CE, Goh PK, Wiede F, Genders AJ, Tran M, Jia Y, Raajendiran A, Brown WA, McLean CA, Sadoshima J, Watt MJ and Tiganis T. Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity. J Clin Invest. 2023;134. PMC10849767.

371 Gambardella J, Santulli G, Fiordelisi A, Cerasuolo FA, Wang X, Prevete N, Sommella E, Avvisato R, Buonaiuto A, Altobelli GG, Rinaldi L, Chiuso F, Feliciello A, Dal Piaz F, Campiglia P, Ciccarelli M, Morisco C, Sadoshima J, Iaccarino G and Sorriento D. Infiltrating macrophages amplify doxorubicin-induced cardiac damage: role of catecholamines. Cell Mol Life Sci. 2023;80:323. PMC10567889.

370 Francisco J, Guan J, Zhang Y, Nakada Y, Mareedu S, Sung EA, Hu CM, Oka S, Zhai P, Sadoshima J and Del Re DP. Suppression of myeloid YAP antagonizes adverse cardiac remodeling during pressure overload stress. J Mol Cell Cardiol. 2023;181:1-14. PMC10524516.

369 Abeliovich H, Debnath J, Ding WX, Jackson WT, Kim DH, Klionsky DJ, Ktistakis N, Margeta M, Munz C, Petersen M, Sadoshima J and Vergne I. Where is the field of autophagy research heading? Autophagy. 2023;19:1049-1054. PMC10012950.

368 Sciarretta S, Forte M and Sadoshima J. Boosting circadian autophagy by means of intermittent time-restricted feeding: a novel anti-ageing strategy? J Cardiovasc Aging. 2022;2. PMC8785976.

367 Sciarretta S, Forte M, Frati G and Sadoshima J. The complex network of mTOR signalling in the heart. Cardiovasc Res. 2022;118:424-439. PMC8932297.

366 Sadoshima J. Myocardin-related transcription factor A in macrophages mediates pathological hypertrophy. Cardiovasc Res. 2022;118:662-663.

365 Sadoshima J. Alternative mitophagy is a major form of mitophagy in the chronically stressed heart. Autophagy. 2022;18:2252-2253. PMC9397446.

364 Sadoshima J. TRAF2 Mediates Physiological Mitophagy. JACC Basic Transl Sci. 2022;7:244-246. PMC8993912.

363 Sadoshima J. Fasting confers stress resistance to skeletal muscle stem cells through non-metabolic actions of beta-hydroxybutyrate: implications in cardioprotection and aging. J Cardiovasc Aging. 2022;2. PMC9311383.

362 Nah J, Zablocki D and Sadoshima J. The role of autophagic cell death in cardiac disease. J Mol Cell Cardiol. 2022;173:16-24.

361 Nah J, Sung EA, Zhai P, Zablocki D and Sadoshima J. Tfeb-Mediated Transcriptional Regulation of Autophagy Induces Autosis during Ischemia/Reperfusion in the Heart. Cells. 2022;11. PMC8773671.

360 Nah J, Shirakabe A, Mukai R, Zhai P, Sung EA, Ivessa A, Mizushima W, Nakada Y, Saito T, Hu C, Jung YK and Sadoshima J. Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart. Cardiovasc Res. 2022;118:2638-2651. PMC10144728.

359 Motino O, Lambertucci F, Anagnostopoulos G, Li S, Nah J, Castoldi F, Senovilla L, Montegut L, Chen H, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Alvarez-Valadez K, Sauvat A, Carbonnier V, Djavaheri-Mergny M, Pietrocola F, Sadoshima J, Maiuri MC, et al. ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis. Proc Natl Acad Sci U S A. 2022;119:e2207344119. PMC9565466.

358 Matsushima S and Sadoshima J. Yin and Yang of NADPH Oxidases in Myocardial Ischemia-Reperfusion. Antioxidants (Basel). 2022;11. PMC9220061.

357 Ketenci M, Zablocki D and Sadoshima J. Mitochondrial Quality Control Mechanisms during Diabetic Cardiomyopathy. JMA J. 2022;5:407-415. PMC9646286.

356 Kashihara T, Mukai R, Oka SI, Zhai P, Nakada Y, Yang Z, Mizushima W, Nakahara T, Warren JS, Abdellatif M and Sadoshima J. YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload. J Clin Invest. 2022;132. PMC8920343.

355 Jaijyan DK, Selariu A, Cruz-Cosme R, Tong M, Yang S, Stefa A, Kekich D, Sadoshima J, Herbig U, Tang Q, Church G, Parrish EL and Zhu H. New intranasal and injectable gene therapy for healthy life extension. Proc Natl Acad Sci U S A. 2022;119:e2121499119. PMC9171804.

354 Ikeda S, Zablocki D and Sadoshima J. The role of autophagy in death of cardiomyocytes. J Mol Cell Cardiol. 2022;165:1-8. PMC8940676.

353 Huang CY, Oka SI, Xu X, Chen CF, Tung CY, Chang YY, Mourad Y, Vehra O, Ivessa A, Yehia G, Romanienko P, Hsu CP and Sadoshima J. PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARalpha and PGC-1alpha. Sci Rep. 2022;12:14576. PMC9418182.

352 Hale ZE and Sadoshima J. Primary Cilia and Their Role in Acquired Heart Disease. Cells. 2022;11. PMC8946116.

351 Xirouchaki CE, Jia Y, McGrath MJ, Greatorex S, Tran M, Merry TL, Hong D, Eramo MJ, Broome SC, Woodhead JST, D'Souza R F, Gallagher J, Salimova E, Huang C, Schittenhelm RB, Sadoshima J, Watt MJ, Mitchell CA and Tiganis T. Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance. Sci Adv. 2021;7:eabl4988. PMC8673768.

350 Wu W, Ziemann M, Huynh K, She G, Pang ZD, Zhang Y, Duong T, Kiriazis H, Pu TT, Bai RY, Li JJ, Zhang Y, Chen MX, Sadoshima J, Deng XL, Meikle PJ and Du XJ. Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice. Theranostics. 2021;11:8993-9008. PMC8419046.

349 Venkatesh S, Baljinnyam E, Tong M, Kashihara T, Yan L, Liu T, Li H, Xie LH, Nakamura M, Oka SI, Suzuki CK, Fraidenraich D and Sadoshima J. Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells. Am J Physiol Regul Integr Comp Physiol. 2021;320:R547-R562. PMC8238141.

348 Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A and Sadoshima J. Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy. Circ Res. 2021;129:1105-1121.

347 Shao D, Zhai P, Hu C, Mukai R, Sciarretta S, Del Re D and Sadoshima J. Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload. Sci Rep. 2021;11:23469. PMC8648781.

346 Sciarretta S, Schirone L and Sadoshima J. Editorial commentary: How to implement research studies on extracellular vesicle administration in myocardial infarction. Trends Cardiovasc Med. 2021;31:416-418.

345 Sciarretta S, Forte M, Castoldi F, Frati G, Versaci F, Sadoshima J, Kroemer G and Maiuri MC. Caloric restriction mimetics for the treatment of cardiovascular diseases. Cardiovasc Res. 2021;117:1434-1449.

344 Sasaki Y, Ikeda Y, Uchikado Y, Akasaki Y, Sadoshima J and Ohishi M. Estrogen Plays a Crucial Role in Rab9-Dependent Mitochondrial Autophagy, Delaying Arterial Senescence. J Am Heart Assoc. 2021;10:e019310. PMC8174372.

343 Saito T, Hamano K and Sadoshima J. Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart. Cardiovasc Res. 2021;117:2730-2741. PMC8932294.

342 Sadoshima J, Kitsis RN and Sciarretta S. Editorial: Mitochondrial Dysfunction and Cardiovascular Diseases. Front Cardiovasc Med. 2021;8:645986. PMC7874211.

341 Sadoshima J. YAP Promotes Infarct Resolution by Stimulating Intercellular Signaling. Circ Res. 2021;129:798-800. PMC8514140.

340 Oka SI, Tang F, Chin A, Ralda G, Xu X, Hu C, Yang Z, Abdellatif M and Sadoshima J. beta-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes. Antioxidants (Basel). 2021;10. PMC8301070.

339 Oka SI, Byun J, Huang CY, Imai N, Ralda G, Zhai P, Xu X, Kashyap S, Warren JS, Alan Maschek J, Tippetts TS, Tong M, Venkatesh S, Ikeda Y, Mizushima W, Kashihara T and Sadoshima J. Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy. Circ Res. 2021;129:114-130. PMC8513534.

338 Nakamura M, Odanovic N, Nakada Y, Dohi S, Zhai P, Ivessa A, Yang Z, Abdellatif M and Sadoshima J. Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure. Cardiovasc Res. 2021;117:2365-2376. PMC8861266.

337 Nakada Y and Sadoshima J. Sleep deficiency and mortality: is the solution in the gut? Cardiovasc Res. 2021;117:e26-e28. PMC8599891.

336 Nah J, Zablocki D and Sadoshima J. The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death. Exp Mol Med. 2021;53:528-536. PMC8102471.

335 Mukai R and Sadoshima J. A Novel Inducer of Autophagy in the Heart. JACC Basic Transl Sci. 2021;6:381-383. PMC8093561.

334 Marian AJ, Asatryan B, Bolli R, Cheedipudi SM, Dhalla NS, Finkel T, Frangogiannis NG, Gurha P, Belmonte JCI, Hare JM, Hong K, Kirshenbaum LA, Lee RT, Leesar MA, Libby P, Madonna R, Nagueh SF, Roberts R, Rosenzweig A, Rouhi L, et al. Editors' Preamble to The Journal of Cardiovascular Aging. J Cardiovasc Aging. 2021;1. PMC8318349.

333 Kyriazis ID, Hoffman M, Gaignebet L, Lucchese AM, Markopoulou E, Palioura D, Wang C, Bannister TD, Christofidou-Solomidou M, Oka SI, Sadoshima J, Koch WJ, Goldberg IJ, Yang VW, Bialkowska AB, Kararigas G and Drosatos K. KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. Circ Res. 2021;128:335-357. PMC7870005.

332 Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, et al. Autophagy in major human diseases. EMBO J. 2021;40:e108863. PMC8488577.

331 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy. 2021;17:1-382. PMC7996087.

330 Ikeda S, Nah J, Shirakabe A, Zhai P, Oka SI, Sciarretta S, Guan KL, Shimokawa H and Sadoshima J. YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases. J Clin Invest. 2021;131. PMC7919732.

329 Fu P, Ramchandran R, Sudhadevi T, Kumar PPK, Krishnan Y, Liu Y, Zhao Y, Parinandi NL, Harijith A, Sadoshima J and Natarajan V. NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium. Antioxidants (Basel). 2021;10. PMC8002602.

328 Chiao YA, Chakraborty AD, Light CM, Tian R, Sadoshima J, Shi X, Gu H and Lee CF. NAD(+) Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy. Circ Heart Fail. 2021;14:e008170. PMC8373812.

327 Chen Y, Maejima Y, Shirakabe A, Yamamoto T, Ikeda Y, Sadoshima J and Zhai P. Ser9 phosphorylation of GSK-3beta promotes aging in the heart through suppression of autophagy. J Cardiovasc Aging. 2021;1. PMC8589323.

326 Tong M, Zablocki D and Sadoshima J. The role of Drp1 in mitophagy and cell death in the heart. J Mol Cell Cardiol. 2020;142:138-145. PMC7545744.

325 Oka SI, Sabry AD, Horiuchi AK, Cawley KM, O'Very SA, Zaitsev MA, Shankar TS, Byun J, Mukai R, Xu X, Torres NS, Kumar A, Yazawa M, Ling J, Taleb I, Saijoh Y, Drakos SG, Sadoshima J and Warren JS. Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1. PLoS One. 2020;15:e0234913. PMC7310723.

324 Oka SI, Chin A, Park JY, Ikeda S, Mizushima W, Ralda G, Zhai P, Tong M, Byun J, Tang F, Einaga Y, Huang CY, Kashihara T, Zhao M, Nah J, Tian B, Hirabayashi Y, Yodoi J and Sadoshima J. Thioredoxin-1 maintains mitochondrial function via mechanistic target of rapamycin signalling in the heart. Cardiovasc Res. 2020;116:1742-1755. PMC7825501.

323 Nakamura M and Sadoshima J. Cardiomyopathy in obesity, insulin resistance and diabetes. J Physiol. 2020;598:2977-2993.

322 Nah J, Zhai P, Huang CY, Fernandez AF, Mareedu S, Levine B and Sadoshima J. Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury. J Clin Invest. 2020;130:2978-2991. PMC7260042.

321 Nah J, Zablocki D and Sadoshima J. Autosis: A New Target to Prevent Cell Death. JACC Basic Transl Sci. 2020;5:857-869. PMC7452304.

320 Fernandez AF, Liu Y, Ginet V, Shi M, Nah J, Zou Z, Zhou A, Posner BA, Xiao G, Tanguy M, Paradis V, Sadoshima J, Rautou PE, Puyal J, Hu MC and Levine B. Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia. JCI Insight. 2020;5. PMC7030824.

319 Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, et al. SIRT1-NOX4 signaling axis regulates cancer cachexia. J Exp Med. 2020;217. PMC7336299.

318 Bellis A, Sorriento D, Fiordelisi A, Izzo R, Sadoshima J, Mauro C, Cerasuolo F, Mancusi C, Barbato E, Pilato E, Trimarco B and Morisco C. Autocrine Bradykinin Release Promotes Ischemic Preconditioning-Induced Cytoprotection in Bovine Aortic Endothelial Cells. Int J Mol Sci. 2020;21. PMC7215376.

317 Zhao WB, Lu Q, Nguyen MN, Su Y, Ziemann M, Wang LN, Kiriazis H, Puthalakath H, Sadoshima J, Hu HY and Du XJ. Stimulation of beta-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway. Br J Pharmacol. 2019;176:2465-2481. PMC6592853.

316 Voigt N and Sadoshima J. Scientists on the Spot: Autophagy and heart disease. Cardiovasc Res. 2019;115:e91-e92. PMC8244630.

315 Venkatesh S, Li M, Saito T, Tong M, Rashed E, Mareedu S, Zhai P, Barcena C, Lopez-Otin C, Yehia G, Sadoshima J and Suzuki CK. Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo. J Mol Cell Cardiol. 2019;128:38-50.

314 Usui S, Chikata A, Takatori O, Takashima SI, Inoue O, Kato T, Murai H, Furusho H, Nomura A, Zablocki D, Kaneko S, Sadoshima J and Takamura M. Endogenous muscle atrophy F-box is involved in the development of cardiac rupture after myocardial infarction. J Mol Cell Cardiol. 2019;126:1-12.

313 Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A and Sadoshima J. Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy. Circ Res. 2019;124:1360-1371. PMC6483841.

312 Tong M and Sadoshima J. Nuclear miR-320 Controls Lipotoxicity. Circ Res. 2019;125:1121-1123. PMC8514138.

311 Saito T, Nah J, Oka SI, Mukai R, Monden Y, Maejima Y, Ikeda Y, Sciarretta S, Liu T, Li H, Baljinnyam E, Fraidenraich D, Fritzky L, Zhai P, Ichinose S, Isobe M, Hsu CP, Kundu M and Sadoshima J. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. J Clin Invest. 2019;129:802-819. PMC6355232.

310 Nguyen MN, Ziemann M, Kiriazis H, Su Y, Thomas Z, Lu Q, Donner DG, Zhao WB, Rafehi H, Sadoshima J, McMullen JR, El-Osta A and Du XJ. Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling. Am J Physiol Heart Circ Physiol. 2019;316:H45-H60.

309 Nakamura M and Sadoshima J. Ketone body can be a fuel substrate for failing heart. Cardiovasc Res. 2019;115:1567-1569. PMC6704386.

308 Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H and Sadoshima J. Glycogen Synthase Kinase-3alpha Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab. 2019;29:1119-1134 e12. PMC6677269.

307 Mukai R, Zablocki D and Sadoshima J. Intermittent Fasting Reverses an Advanced Form of Cardiomyopathy. J Am Heart Assoc. 2019;8:e011863. PMC6405682.

306 Kashihara T, Zablocki D and Sadoshima J. YAP-dependent metabolic remodeling in local lymph node boosts the function of cancer cells. Biotarget. 2019;3. PMC6738959.

305 Kashihara T and Sadoshima J. Role of YAP/TAZ in Energy Metabolism in the Heart. J Cardiovasc Pharmacol. 2019;74:483-490. PMC6905197.

304 Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ and Drosatos K. Dual peroxisome-proliferator-activated-receptor-alpha/gamma activation inhibits SIRT1-PGC1alpha axis and causes cardiac dysfunction. JCI Insight. 2019;5. PMC6777908.

303 Ikeda S, Mukai R, Mizushima W, Zhai P, Oka SI, Nakamura M, Del Re DP, Sciarretta S, Hsu CP, Shimokawa H and Sadoshima J. Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart. JACC Basic Transl Sci. 2019;4:611-622. PMC6872826.

302 Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS and Sadoshima J. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circ Res. 2019;124:292-305. PMC6645688.

301 Gorski PA, Jang SP, Jeong D, Lee A, Lee P, Oh JG, Chepurko V, Yang DK, Kwak TH, Eom SH, Park ZY, Yoo YJ, Kim DH, Kook H, Sunagawa Y, Morimoto T, Hasegawa K, Sadoshima J, Vangheluwe P, Hajjar RJ, et al. Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca(2+)-ATPase in Heart Failure. Circ Res. 2019;124:e63-e80. PMC6483854.

300 Francisco J, Byun J, Zhang Y, Kalloo OB, Mizushima W, Oka S, Zhai P, Sadoshima J and Del Re DP. The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium. J Biol Chem. 2019;294:13131-13144. PMC6721958.

299 Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, Sica V, Carmona-Gutierrez D, Zimmermann A, Pendl T, Tadic J, Bergmann M, Hofer SJ, Domuz L, Lachkar S, Markaki M, Tavernarakis N, Sadoshima J, Madeo F, Kepp O, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019;11:e10469. PMC6835206.

298 Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019;10:651. PMC6381180.

297 Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Shigeta M, Kiyonari H, Umemura M, Yokoyama U, Sadoshima J and Ishikawa Y. Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism. Cell Death Dis. 2019;10:549. PMC6639386.

296 Byun J, Oka SI, Imai N, Huang CY, Ralda G, Zhai P, Ikeda Y, Ikeda S and Sadoshima J. Both gain and loss of Nampt function promote pressure overload-induced heart failure. Am J Physiol Heart Circ Physiol. 2019;317:H711-H725. PMC6843022.

295 Byun J, Del Re DP, Zhai P, Ikeda S, Shirakabe A, Mizushima W, Miyamoto S, Brown JH and Sadoshima J. Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload. J Biol Chem. 2019;294:3603-3617. PMC6416448.

294 Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, Schesing K, Tang F, Tian Y, Babu G, Ralda G, Warren JS, Cho J, Sadoshima J and Oka SI. Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1alpha (Peroxisome Proliferator-Activated Receptor-gamma Coactivator-1alpha) Dysregulation. Circ Heart Fail. 2019;12:e005529. PMC6392084.

293 Abdullah CS, Alam S, Aishwarya R, Miriyala S, Bhuiyan MAN, Panchatcharam M, Pattillo CB, Orr AW, Sadoshima J, Hill JA and Bhuiyan MS. Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration. Sci Rep. 2019;9:2002. PMC6376057.

292 Tham YK, Huynh K, Mellett NA, Henstridge DC, Kiriazis H, Ooi JYY, Matsumoto A, Patterson NL, Sadoshima J, Meikle PJ and McMullen JR. Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:219-234.

291 Sciarretta S, Yee D, Nagarajan N, Bianchi F, Saito T, Valenti V, Tong M, Del Re DP, Vecchione C, Schirone L, Forte M, Rubattu S, Shirakabe A, Boppana VS, Volpe M, Frati G, Zhai P and Sadoshima J. Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction. J Am Coll Cardiol. 2018;71:1999-2010. PMC6347412.

290 Sciarretta S, Maejima Y, Zablocki D and Sadoshima J. The Role of Autophagy in the Heart. Annu Rev Physiol. 2018;80:1-26.

289 Sciarretta S, Forte M, Frati G and Sadoshima J. New Insights Into the Role of mTOR Signaling in the Cardiovascular System. Circ Res. 2018;122:489-505. PMC6398933.

288 Sauvat A, Chen G, Muller K, Tong M, Aprahamian F, Durand S, Cerrato G, Bezu L, Leduc M, Franz J, Rockenfeller P, Sadoshima J, Madeo F, Kepp O and Kroemer G. Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids. EBioMedicine. 2018;30:261-272. PMC5952403.

287 Pietrocola F, Castoldi F, Markaki M, Lachkar S, Chen G, Enot DP, Durand S, Bossut N, Tong M, Malik SA, Loos F, Dupont N, Marino G, Abdelkader N, Madeo F, Maiuri MC, Kroemer R, Codogno P, Sadoshima J, Tavernarakis N, et al. Aspirin Recapitulates Features of Caloric Restriction. Cell Rep. 2018;22:2395-2407. PMC5848858.

286 Nguyen MN, Su Y, Vizi D, Fang L, Ellims AH, Zhao WB, Kiriazis H, Gao XM, Sadoshima J, Taylor AJ, McMullen JR, Dart AM, Kaye DM and Du XJ. Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure. Sci Rep. 2018;8:8213. PMC5973942.

285 Nakamura M and Sadoshima J. Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol. 2018;15:387-407.

284 Madrigal-Matute J, Scorrano L and Sadoshima J. Leducq Network: Modulating Autophagy to Treat Cardiovascular Disease. Circ Res. 2018;123:323-325. PMC6082024.

283 Bidwell PA, Liu GS, Nagarajan N, Lam CK, Haghighi K, Gardner G, Cai WF, Zhao W, Mugge L, Vafiadaki E, Sanoudou D, Rubinstein J, Lebeche D, Hajjar R, Sadoshima J and Kranias EG. HAX-1 regulates SERCA2a oxidation and degradation. J Mol Cell Cardiol. 2018;114:220-233. PMC5801168.

282 Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, et al. Why publish in the American Journal of Physiology-Heart and Circulatory Physiology? Am J Physiol Heart Circ Physiol. 2017;313:H221-H223.

281 Warren JS, Oka SI, Zablocki D and Sadoshima J. Metabolic reprogramming via PPARalpha signaling in cardiac hypertrophy and failure: From metabolomics to epigenetics. Am J Physiol Heart Circ Physiol. 2017;313:H584-H596. PMC6425516.

280 Sciarretta S, De Falco E, Frati G and Sadoshima J. How to be young at heart? miR-22 as a potential therapeutic target to boost autophagy and protect the old myocardium. Ann Transl Med. 2017;5:52. PMC5326662.

279 Saito T and Sadoshima J. Unexpected Functional Consequences of the Loss of the Autophagy-Related Conjugation System. Circ Res. 2017;120:610-612. PMC5319734.

278 Sadoshima J and Tomoike H. What Should We Learn From the Recent Decline of Basic Cardiovascular Science in Japan? Circ Res. 2017;121:314-316. PMC5560069.

277 Sadoshima J. Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School. Circ Res. 2017;121:1127-1129. PMC5762121.

276 Oka SI, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, Yaginuma H, Saito T, Nagarajan N, Zhai P, Bhat S, Schesing K, Shao D, Hirabayashi Y, Yodoi J, Sciarretta S and Sadoshima J. Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes. J Biol Chem. 2017;292:18988-19000. PMC5704480.

275 Nah J, Miyamoto S and Sadoshima J. Mitophagy as a Protective Mechanism against Myocardial Stress. Compr Physiol. 2017;7:1407-1424.

274 Nagarajan N, Oka S and Sadoshima J. Modulation of signaling mechanisms in the heart by thioredoxin 1. Free Radic Biol Med. 2017;109:125-131. PMC5462876.

273 Mizushima W and Sadoshima J. BAG3 plays a central role in proteostasis in the heart. J Clin Invest. 2017;127:2900-2903. PMC5531392.

272 Kang H, Oka S, Lee DY, Park J, Aponte AM, Jung YS, Bitterman J, Zhai P, He Y, Kooshapur H, Ghirlando R, Tjandra N, Lee SB, Kim MK, Sadoshima J and Chung JH. Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins. Nat Commun. 2017;8:15560. PMC5440690.

271 Huang C, Alapa M, Shu P, Nagarajan N, Wu C, Sadoshima J, Kholodovych V, Li H and Beuve A. Guanylyl cyclase sensitivity to nitric oxide is protected by a thiol oxidation-driven interaction with thioredoxin-1. J Biol Chem. 2017;292:14362-14370. PMC5582831.

270 Hsu YJ, Hsu SC, Hsu CP, Chen YH, Chang YL, Sadoshima J, Huang SM, Tsai CS and Lin CY. Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model. Int J Cardiol. 2017;228:543-552.

269 Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn GW, II, Sadoshima J, Ellisman MH and Gustafsson AB. A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance. Nat Commun. 2017;8:14050. PMC5290275.

268 Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, Stekovic S, Schipke J, Magnes C, Schmidt A, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Carmona-Gutierrez D, Pietrocola F, Pieber TR, Sigrist SJ, Linke WA, Muhlfeld C, et al. Dietary spermidine for lowering high blood pressure. Autophagy. 2017;13:767-769. PMC5381711.

267 Carrizzo A, Vecchione C, Damato A, di Nonno F, Ambrosio M, Pompeo F, Cappello E, Capocci L, Peruzzi M, Valenti V, Biondi-Zoccai G, Marullo AG, Palmerio S, Carnevale R, Spinelli CC, Puca AA, Rubattu S, Volpe M, Sadoshima J, Frati G, et al. Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction. J Am Heart Assoc. 2017;6. PMC5524008.

266 Cao Y, Bojjireddy N, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD and Tian R. Activation of gamma2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury. Circ Res. 2017;121:1182-1191. PMC5659937.

265 Byun S, Kim YC, Zhang Y, Kong B, Guo G, Sadoshima J, Ma J, Kemper B and Kemper JK. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J. 2017;36:1755-1769. PMC5470039.

264 V DA, Perez V, Mazo T, Munoz MC, Dominici FP, Carreras MC, Poderoso JJ, Sadoshima J and Gelpi RJ. Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1. Oncotarget. 2016;7:11889-98. PMC4914256.

263 Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, Cohen RA and Zeng C. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 2016;92:30-40. PMC5008453.

262 Tong M and Sadoshima J. Mitochondrial autophagy in cardiomyopathy. Curr Opin Genet Dev. 2016;38:8-15. PMC5028232.

261 Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B and Sadoshima J. Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure. Circulation. 2016;133:1249-63. PMC4811679.

260 Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B and Sadoshima J. Response by Shirakabe et al to Letter Regarding Article, "Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure". Circulation. 2016;134:e75-6. PMC5051345.

259 Shirakabe A, Ikeda Y, Sciarretta S, Zablocki DK and Sadoshima J. Aging and Autophagy in the Heart. Circ Res. 2016;118:1563-76. PMC4869999.

258 Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson AB, Kitsis RN and Sadoshima J. Evaluating mitochondrial autophagy in the mouse heart. J Mol Cell Cardiol. 2016;92:134-9.

257 Perez V, D'Annunzio V, Valdez LB, Zaobornyj T, Bombicino S, Mazo T, Carbajosa NL, Gironacci MM, Boveris A, Sadoshima J and Gelpi RJ. Thioredoxin-1 Attenuates Ventricular and Mitochondrial Postischemic Dysfunction in the Stunned Myocardium of Transgenic Mice. Antioxid Redox Signal. 2016;25:78-88.

256 Nishimura A, Ago T, Kuroda J, Arimura K, Tachibana M, Nakamura K, Wakisaka Y, Sadoshima J, Iihara K and Kitazono T. Detrimental role of pericyte Nox4 in the acute phase of brain ischemia. J Cereb Blood Flow Metab. 2016;36:1143-54. PMC4908615.

255 Nakamura M, Zhai P, Del Re DP, Maejima Y and Sadoshima J. Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI Insight. 2016;1. PMC4869724.

254 Nah J, Fernandez AF, Kitsis RN, Levine B and Sadoshima J. Does Autophagy Mediate Cardiac Myocyte Death During Stress? Circ Res. 2016;119:893-5. PMC5161244.

253 Matsushima S, Zablocki D, Tsutsui H and Sadoshima J. Poldip2 negatively regulates matrix synthesis at focal adhesions. J Mol Cell Cardiol. 2016;94:10-12.

252 Matsushima S, Kuroda J, Zhai P, Liu T, Ikeda S, Nagarajan N, Oka S, Yokota T, Kinugawa S, Hsu CP, Li H, Tsutsui H and Sadoshima J. Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J Clin Invest. 2016;126:3403-16. PMC5004961.

251 Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park J, Hsu CP, Tian B, Pan D, Sadoshima J and Del Re DP. NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart. Circ Res. 2016;119:596-606. PMC4992450.

250 Maejima Y, Isobe M and Sadoshima J. Regulation of autophagy by Beclin 1 in the heart. J Mol Cell Cardiol. 2016;95:19-25. PMC4861696.

249 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12:1-222. PMC4835977.

248 Ishikita A, Matoba T, Ikeda G, Koga J, Mao Y, Nakano K, Takeuchi O, Sadoshima J and Egashira K. Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction. J Am Heart Assoc. 2016;5. PMC5015412.

247 Ikeda S and Sadoshima J. Regulation of Myocardial Cell Growth and Death by the Hippo Pathway. Circ J. 2016;80:1511-9.

246 Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016;22:1428-1438. PMC5806691.

245 Bernardo BC, Ooi JY, Matsumoto A, Tham YK, Singla S, Kiriazis H, Patterson NL, Sadoshima J, Obad S, Lin RC and McMullen JR. Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: identification of sex-, disease- and treatment-regulated miRNAs. J Physiol. 2016;594:5959-5974. PMC5063924.

244 Zablocki D and Sadoshima J. Inside-Out Signaling: Moving the AT1 Receptor in to Get the Message Out. Circulation. 2015;131:2097-100. PMC4470784.

243 Yang Y, Del Re DP, Nakano N, Sciarretta S, Zhai P, Park J, Sayed D, Shirakabe A, Matsushima S, Park Y, Tian B, Abdellatif M and Sadoshima J. miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival. Circ Res. 2015;117:891-904. PMC4747867.

242 Tzeng J, Byun J, Park JY, Yamamoto T, Schesing K, Tian B, Sadoshima J and Oka S. An Ideal PPAR Response Element Bound to and Activated by PPARalpha. PLoS One. 2015;10:e0134996. PMC4524655.

241 Tong X, Khandelwal AR, Qin Z, Wu X, Chen L, Ago T, Sadoshima J and Cohen RA. Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia. J Mol Cell Cardiol. 2015;89:185-94.

240 Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe M, Frati G, Li H and Sadoshima J. mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Rep. 2015;11:125-36. PMC4417361.

239 Sciarretta S, Yee D, Ammann P, Nagarajan N, Volpe M, Frati G and Sadoshima J. Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes. Clin Sci (Lond). 2015;128:387-403.

238 Sciarretta S, Boppana VS, Umapathi M, Frati G and Sadoshima J. Boosting autophagy in the diabetic heart: a translational perspective. Cardiovasc Diagn Ther. 2015;5:394-402. PMC4609904.

237 Saito T and Sadoshima J. Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ Res. 2015;116:1477-90. PMC4419704.

236 Oka S, Zhai P, Yamamoto T, Ikeda Y, Byun J, Hsu CP and Sadoshima J. Peroxisome Proliferator Activated Receptor-alpha Association With Silent Information Regulator 1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart. Circ Heart Fail. 2015;8:1123-32. PMC4651813.

235 Moyzis AG, Sadoshima J and Gustafsson AB. Mending a broken heart: the role of mitophagy in cardioprotection. Am J Physiol Heart Circ Physiol. 2015;308:H183-92. PMC4312945.

234 Matsushima S and Sadoshima J. The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol. 2015;309:H1375-89. PMC4666968.

233 Maejima Y, Chen Y, Isobe M, Gustafsson AB, Kitsis RN and Sadoshima J. Recent progress in research on molecular mechanisms of autophagy in the heart. Am J Physiol Heart Circ Physiol. 2015;308:H259-68. PMC4329480.

232 Liu T, Wu C, Jain MR, Nagarajan N, Yan L, Dai H, Cui C, Baykal A, Pan S, Ago T, Sadoshima J and Li H. Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation. Biochim Biophys Acta. 2015;1854:1816-1822. PMC4721509.

231 Kyrychenko S, Kyrychenko V, Badr MA, Ikeda Y, Sadoshima J and Shirokova N. Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy. Cardiovasc Res. 2015;108:324-34. PMC4648202.

230 Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Abdellatif M and Sadoshima J. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res. 2015;116:264-78.

229 Ikeda Y, Shirakabe A, Brady C, Zablocki D, Ohishi M and Sadoshima J. Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system. J Mol Cell Cardiol. 2015;78:116-22. PMC4268018.

228 Ago T and Sadoshima J. From Contractile Enhancement to Pathological Hypertrophy: Angiotensin II-Induced Nox2-Mediated Reactive Oxygen Species. J Am Coll Cardiol. 2015;66:273-277.

227 Yu Q, Lee CF, Wang W, Karamanlidis G, Kuroda J, Matsushima S, Sadoshima J and Tian R. Elimination of NADPH oxidase activity promotes reductive stress and sensitizes the heart to ischemic injury. J Am Heart Assoc. 2014;3:e000555. PMC3959718.

226 Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S and Sadoshima J. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One. 2014;9:e98972. PMC4048236.

225 Wu C, Jain MR, Li Q, Oka S, Li W, Kong AN, Nagarajan N, Sadoshima J, Simmons WJ and Li H. Identification of novel nuclear targets of human thioredoxin 1. Mol Cell Proteomics. 2014;13:3507-18. PMC4256501.

224 Wackerhage H, Del Re DP, Judson RN, Sudol M and Sadoshima J. The Hippo signal transduction network in skeletal and cardiac muscle. Sci Signal. 2014;7:re4.

223 Shao D, Zhai P, Del Re DP, Sciarretta S, Yabuta N, Nojima H, Lim DS, Pan D and Sadoshima J. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun. 2014;5:3315. PMC3962829.

222 Shao D, Oka S, Liu T, Zhai P, Ago T, Sciarretta S, Li H and Sadoshima J. A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation. Cell Metab. 2014;19:232-45. PMC3937768.

221 Sciarretta S, Yee D, Shenoy V, Nagarajan N and Sadoshima J. The importance of autophagy in cardioprotection. High Blood Press Cardiovasc Prev. 2014;21:21-8.

220 Sciarretta S, Volpe M and Sadoshima J. Mammalian target of rapamycin signaling in cardiac physiology and disease. Circ Res. 2014;114:549-64. PMC3995130.

219 Sciarretta S, Volpe M and Sadoshima J. NOX4 regulates autophagy during energy deprivation. Autophagy. 2014;10:699-701. PMC4091158.

218 Sapra G, Tham YK, Cemerlang N, Matsumoto A, Kiriazis H, Bernardo BC, Henstridge DC, Ooi JY, Pretorius L, Boey EJ, Lim L, Sadoshima J, Meikle PJ, Mellet NA, Woodcock EA, Marasco S, Ueyama T, Du XJ, Febbraio MA and McMullen JR. The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice. Nat Commun. 2014;5:5705.

217 Sadoshima J and Weiss JN. Cardiac fibroblasts: the good, the bad, the ugly, the beautiful. J Mol Cell Cardiol. 2014;70:1. PMC4826044.

216 Nakamura M and Sadoshima J. Heart over mind: metabolic control of white adipose tissue and liver. EMBO Mol Med. 2014;6:1521-4. PMC4287972.

215 Matsushima S, Tsutsui H and Sadoshima J. Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion. Trends Cardiovasc Med. 2014;24:202-5. PMC4119873.

214 Maejima Y, Usui S, Zhai P, Takamura M, Kaneko S, Zablocki D, Yokota M, Isobe M and Sadoshima J. Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A. Circ Heart Fail. 2014;7:479-90. PMC4031295.

213 Maejima Y and Sadoshima J. SUMOylation: a novel protein quality control modifier in the heart. Circ Res. 2014;115:686-9. PMC4181369.

212 Lee A, Jeong D, Mitsuyama S, Oh JG, Liang L, Ikeda Y, Sadoshima J, Hajjar RJ and Kho C. The role of SUMO-1 in cardiac oxidative stress and hypertrophy. Antioxid Redox Signal. 2014;21:1986-2001. PMC4208582.

211 Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J and Guan KL. Rag GTPases are cardioprotective by regulating lysosomal function. Nat Commun. 2014;5:4241. PMC4100214.

210 Ikeda Y, Sciarretta S, Nagarajan N, Rubattu S, Volpe M, Frati G and Sadoshima J. New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart. Oxid Med Cell Longev. 2014;2014:210934. PMC4124219.

209 Hsu CP, Yamamoto T, Oka S and Sadoshima J. The function of nicotinamide phosphoribosyltransferase in the heart. DNA Repair (Amst). 2014;23:64-8. PMC4254158.

208 Hasumi Y, Baba M, Hasumi H, Huang Y, Lang M, Reindorf R, Oh HB, Sciarretta S, Nagashima K, Haines DC, Schneider MD, Adelstein RS, Schmidt LS, Sadoshima J and Marston Linehan W. Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation. Hum Mol Genet. 2014;23:5706-19. PMC4189904.

207 Del Re DP and Sadoshima J. Elucidating ERK2 function in the heart. J Mol Cell Cardiol. 2014;72:336-8.

206 Del Re DP, Matsuda T, Zhai P, Maejima Y, Jain MR, Liu T, Li H, Hsu CP and Sadoshima J. Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL. Mol Cell. 2014;54:639-50. PMC4074544.

205 Chen L, Xiao J, Kuroda J, Ago T, Sadoshima J, Cohen RA and Tong X. Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines. Biochim Biophys Acta. 2014;1842:2489-99.

204 Banerjee Mustafi S, Grose JH, Zhang H, Pratt GW, Sadoshima J, Christians ES and Benjamin IJ. Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system. Antioxid Redox Signal. 2014;20:2891-906. PMC4039002.

203 Zschauer TC, Matsushima S, Altschmied J, Shao D, Sadoshima J and Haendeler J. Interacting with thioredoxin-1--disease or no disease? Antioxid Redox Signal. 2013;18:1053-62. PMC3567779.

202 Zablocki D and Sadoshima J. Angiotensin II and oxidative stress in the failing heart. Antioxid Redox Signal. 2013;19:1095-109. PMC3771547.

201 Zablocki D and Sadoshima J. Solving the cardiac hypertrophy riddle: The angiotensin II-mechanical stress connection. Circ Res. 2013;113:1192-5.

200 Weiss CS, Ochs MM, Hagenmueller M, Streit MR, Malekar P, Riffel JH, Buss SJ, Weiss KH, Sadoshima J, Katus HA and Hardt SE. DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3beta on eIF2Bepsilon. PLoS One. 2013;8:e70848. PMC3762802.

199 Sciarretta S, Zhai P, Shao D, Zablocki D, Nagarajan N, Terada LS, Volpe M and Sadoshima J. Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2alpha/activating transcription factor 4 pathway. Circ Res. 2013;113:1253-64. PMC3937770.

198 Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M, Castello L, Calvieri C, Eberini I, Sadoshima J, Hobbs AJ, Volpe M and Rubattu S. C2238 atrial natriuretic peptide molecular variant is associated with endothelial damage and dysfunction through natriuretic peptide receptor C signaling. Circ Res. 2013;112:1355-64.

197 Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J and Calvert JW. Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure. Arterioscler Thromb Vasc Biol. 2013;33:744-51. PMC3827725.

196 Matsushima S, Kuroda J, Ago T, Zhai P, Park JY, Xie LH, Tian B and Sadoshima J. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circ Res. 2013;112:651-63. PMC3574183.

195 Matsushima S, Kuroda J, Ago T, Zhai P, Ikeda Y, Oka S, Fong GH, Tian R and Sadoshima J. Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1alpha and upregulation of peroxisome proliferator-activated receptor-alpha. Circ Res. 2013;112:1135-49. PMC3871171.

194 Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M and Sadoshima J. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med. 2013;19:1478-88. PMC3823824.

193 Lavandero S, Troncoso R, Rothermel BA, Martinet W, Sadoshima J and Hill JA. Cardiovascular autophagy: concepts, controversies, and perspectives. Autophagy. 2013;9:1455-66.

192 Hariharan N, Ikeda Y, Hong C, Alcendor RR, Usui S, Gao S, Maejima Y and Sadoshima J. Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart. PLoS One. 2013;8:e51632. PMC3538681.

191 Del Re DP, Yang Y, Nakano N, Cho J, Zhai P, Yamamoto T, Zhang N, Yabuta N, Nojima H, Pan D and Sadoshima J. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem. 2013;288:3977-88. PMC3567650.

190 Bhuiyan MS, Pattison JS, Osinska H, James J, Gulick J, McLendon PM, Hill JA, Sadoshima J and Robbins J. Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest. 2013;123:5284-97. PMC3859422.

189 Zhai P and Sadoshima J. Glycogen synthase kinase-3beta controls autophagy during myocardial ischemia and reperfusion. Autophagy. 2012;8:138-9. PMC3335996.

188 Shao D, Oka S, Brady CD, Haendeler J, Eaton P and Sadoshima J. Redox modification of cell signaling in the cardiovascular system. J Mol Cell Cardiol. 2012;52:550-8. PMC3237398.

187 Sciarretta S, Zhai P, Volpe M and Sadoshima J. Pharmacological modulation of autophagy during cardiac stress. J Cardiovasc Pharmacol. 2012;60:235-41. PMC3514409.

186 Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G and Sadoshima J. Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation. 2012;125:1134-46. PMC3337789.

185 Sciarretta S, Volpe M and Sadoshima J. Is reactivation of autophagy a possible therapeutic solution for obesity and metabolic syndrome? Autophagy. 2012;8:1252-4. PMC3679239.

184 Oka S, Zhai P, Alcendor R, Park JY, Tian B and Sadoshima J. Suppression of ERR targets by a PPARalpha/Sirt1 complex in the failing heart. Cell Cycle. 2012;11:856-64. PMC3323793.

183 Oka S, Hsu CP and Sadoshima J. Regulation of cell survival and death by pyridine nucleotides. Circ Res. 2012;111:611-27. PMC3523888.

182 Nakamura M, Bhatnagar A and Sadoshima J. Overview of pyridine nucleotides review series. Circ Res. 2012;111:604-10. PMC3523884.

181 Messaoudi S, Zhang AD, Griol-Charhbili V, Escoubet B, Sadoshima J, Farman N and Jaisser F. The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling. PLoS One. 2012;7:e30156. PMC3264592.

180 Maejima Y, Galeotti J, Molkentin JD, Sadoshima J and Zhai P. Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3alpha during aging and hemodynamic pressure overload. Am J Physiol Heart Circ Physiol. 2012;303:H979-88. PMC3774208.

179 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012;8:445-544. PMC3404883.

178 Del Re DP and Sadoshima J. Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1. Circ Res. 2012;110:1154-6. PMC3350802.

177 Del Re DP and Sadoshima J. RASSF1A Signaling in the Heart: Novel Functions beyond Tumor Suppression. Mol Biol Int. 2012;2012:154283. PMC3337625.

176 Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL and Lee Y. Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One. 2012;7:e51621. PMC3517560.

175 Zhao Q, Beck AJ, Vitale JM, Schneider JS, Chang C, Gao S, del Re D, Bhaumik M, Yehia G, Sadoshima J and Fraidenraich D. Injection of wild type embryonic stem cells into Mst1 transgenic blastocysts prevents adult-onset cardiomyopathy. Stem Cell Rev Rep. 2011;7:326-30. PMC3244830.

174 Zhai P, Sciarretta S, Galeotti J, Volpe M and Sadoshima J. Differential roles of GSK-3beta during myocardial ischemia and ischemia/reperfusion. Circ Res. 2011;109:502-11. PMC3158807.

173 Zablocki D and Sadoshima J. Knocking out angiotensin II in the heart. Curr Hypertens Rep. 2011;13:129-35. PMC3278322.

172 Yang Y, Ago T, Zhai P, Abdellatif M and Sadoshima J. Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7. Circ Res. 2011;108:305-13. PMC3249645.

171 Yamamoto T and Sadoshima J. Protection of the heart against ischemia/reperfusion by silent information regulator 1. Trends Cardiovasc Med. 2011;21:27-32. PMC3326382.

170 Wu C, Parrott AM, Liu T, Jain MR, Yang Y, Sadoshima J and Li H. Distinction of thioredoxin transnitrosylation and denitrosylation target proteins by the ICAT quantitative approach. J Proteomics. 2011;74:2498-509. PMC3253718.

169 Wu C, Parrott AM, Fu C, Liu T, Marino SM, Gladyshev VN, Jain MR, Baykal AT, Li Q, Oka S, Sadoshima J, Beuve A, Simmons WJ and Li H. Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies. Antioxid Redox Signal. 2011;15:2565-604. PMC3176348.

168 Usui S, Maejima Y, Pain J, Hong C, Cho J, Park JY, Zablocki D, Tian B, Glass DJ and Sadoshima J. Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ Res. 2011;109:161-71. PMC3257317.

167 Sciarretta S, Hariharan N, Monden Y, Zablocki D and Sadoshima J. Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart? Pediatr Cardiol. 2011;32:275-81. PMC3261079.

166 Sadoshima J and Hare JM. Meeting report for Basic Cardiovascular Sciences 2011 Scientific Sessions: from concept to clinic: leading cardiovascular translational science. Circ Res. 2011;109:1204-5.

165 Sadoshima J. Sirt3 targets mPTP and prevents aging in the heart. Aging (Albany NY). 2011;3:12-3. PMC3047131.

164 Park JY, Li W, Zheng D, Zhai P, Zhao Y, Matsuda T, Vatner SF, Sadoshima J and Tian B. Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules. PLoS One. 2011;6:e22391. PMC3142162.

163 Oka S, Alcendor R, Zhai P, Park JY, Shao D, Cho J, Yamamoto T, Tian B and Sadoshima J. PPARalpha-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway. Cell Metab. 2011;14:598-611. PMC3217210.

162 Matsushima S, Zablocki D and Sadoshima J. Application of recombinant thioredoxin1 for treatment of heart disease. J Mol Cell Cardiol. 2011;51:570-3. PMC3034160.

161 Maejima Y, Kuroda J, Matsushima S, Ago T and Sadoshima J. Regulation of myocardial growth and death by NADPH oxidase. J Mol Cell Cardiol. 2011;50:408-16. PMC3257581.

160 Lin YR, Kim K, Yang Y, Ivessa A, Sadoshima J and Park Y. Regulation of longevity by regulator of G-protein signaling protein, Loco. Aging Cell. 2011;10:438-47.

159 Kajimoto K, Shao D, Takagi H, Maceri G, Zablocki D, Mukai H, Ono Y and Sadoshima J. Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2011;300:H191-200. PMC3023260.

158 Hariharan N, Zhai P and Sadoshima J. Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal. 2011;14:2179-90. PMC3085947.

157 Del Re DP and Sadoshima J. Is Raf1 a nexus for cardiac hypertrophic signaling in human disease? J Mol Cell Cardiol. 2011;51:1-3.

156 Cho J, Zhai P, Maejima Y and Sadoshima J. Myocardial injection with GSK-3beta-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction. Circ Res. 2011;108:478-89. PMC3109296.

155 Ago T, Kuroda J, Kamouchi M, Sadoshima J and Kitazono T. Pathophysiological roles of NADPH oxidase/nox family proteins in the vascular system. -Review and perspective. Circ J. 2011;75:1791-800.

154 Zablocki D and Sadoshima J. The one-two punch: knocking out angiotensin II in the heart. J Clin Invest. 2010;120:1028-31. PMC2846074.

153 Wu C, Liu T, Chen W, Oka S, Fu C, Jain MR, Parrott AM, Baykal AT, Sadoshima J and Li H. Redox regulatory mechanism of transnitrosylation by thioredoxin. Mol Cell Proteomics. 2010;9:2262-75. PMC2953919.

152 Takagi H, Hsu CP, Kajimoto K, Shao D, Yang Y, Maejima Y, Zhai P, Yehia G, Yamada C, Zablocki D and Sadoshima J. Activation of PKN mediates survival of cardiac myocytes in the heart during ischemia/reperfusion. Circ Res. 2010;107:642-9. PMC3081566.

151 Sciarretta S and Sadoshima J. New insights into the molecular phenotype of eccentric hypertrophy. J Mol Cell Cardiol. 2010;49:153-6. PMC2902863.

150 Kuroda J and Sadoshima J. NADPH oxidase and cardiac failure. J Cardiovasc Transl Res. 2010;3:314-20. PMC3257318.

149 Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD and Sadoshima J. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A. 2010;107:15565-70. PMC2932625.

148 Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, Hariharan N, Shao D, Takagi H, Oka S and Sadoshima J. Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation. 2010;122:2170-82. PMC3003297.

147 Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA and Sadoshima J. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res. 2010;107:1470-82. PMC3011986.

146 Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP and Jain MK. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med. 2010;2:26ra26. PMC3003709.

145 Del Re DP, Matsuda T, Zhai P, Gao S, Clark GJ, Van Der Weyden L and Sadoshima J. Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J Clin Invest. 2010;120:3555-67. PMC2947240.

144 Chu PY, Mariani J, Finch S, McMullen JR, Sadoshima J, Marshall T and Kaye DM. Bone marrow-derived cells contribute to fibrosis in the chronically failing heart. Am J Pathol. 2010;176:1735-42. PMC2843465.

143 Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, et al. Dietary restriction: standing up for sirtuins. Science. 2010;329:1012-3; author reply 1013-4. PMC3985480.

142 Ago T, Yang Y, Zhai P and Sadoshima J. Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload. J Cardiovasc Transl Res. 2010;3:304-13. PMC3036765.

141 Ago T, Matsushima S, Kuroda J, Zablocki D, Kitazono T and Sadoshima J. The NADPH oxidase Nox4 and aging in the heart. Aging (Albany NY). 2010;2:1012-6. PMC3034169.

140 Ago T, Kuroda J, Pain J, Fu C, Li H and Sadoshima J. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res. 2010;106:1253-64. PMC2855780.

139 Yan L, Sadoshima J, Vatner DE and Vatner SF. Autophagy in ischemic preconditioning and hibernating myocardium. Autophagy. 2009;5:709-12.

138 Wu C, Yan L, Depre C, Dhar SK, Shen YT, Sadoshima J, Vatner SF and Vatner DE. Cytochrome c oxidase III as a mechanism for apoptosis in heart failure following myocardial infarction. Am J Physiol Cell Physiol. 2009;297:C928-34. PMC2770743.

137 Woodcock EA, Grubb DR, Filtz TM, Marasco S, Luo J, McLeod-Dryden TJ, Kaye DM, Sadoshima J, Du XJ, Wong C, McMullen JR and Dart AM. Selective activation of the "b" splice variant of phospholipase Cbeta1 in chronically dilated human and mouse atria. J Mol Cell Cardiol. 2009;47:676-83.

136 Vatner SF, Yan L, Ishikawa Y, Vatner DE and Sadoshima J. Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress. Circ J. 2009;73:195-200.

135 Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF and Abdellatif M. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res. 2009;104:879-86. PMC3332328.

134 Pretorius L, Du XJ, Woodcock EA, Kiriazis H, Lin RC, Marasco S, Medcalf RL, Ming Z, Head GA, Tan JW, Cemerlang N, Sadoshima J, Shioi T, Izumo S, Lukoshkova EV, Dart AM, Jennings GL and McMullen JR. Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation. Am J Pathol. 2009;175:998-1009. PMC2731119.

133 Perry CN, Kyoi S, Hariharan N, Takagi H, Sadoshima J and Gottlieb RA. Novel methods for measuring cardiac autophagy in vivo. Methods Enzymol. 2009;453:325-42. PMC3658837.

132 Oka S, Ago T, Kitazono T, Zablocki D and Sadoshima J. The role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy. J Mol Med (Berl). 2009;87:785-91.

131 Nishida K, Kyoi S, Yamaguchi O, Sadoshima J and Otsu K. The role of autophagy in the heart. Cell Death Differ. 2009;16:31-8.

130 Hu CL, Chandra R, Ge H, Pain J, Yan L, Babu G, Depre C, Iwatsubo K, Ishikawa Y, Sadoshima J, Vatner SF and Vatner DE. Adenylyl cyclase type 5 protein expression during cardiac development and stress. Am J Physiol Heart Circ Physiol. 2009;297:H1776-82. PMC2781380.

129 Hsu CP, Oka S, Shao D, Hariharan N and Sadoshima J. Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res. 2009;105:481-91. PMC2765790.

128 Hsu CP, Hariharan N, Alcendor RR, Oka S and Sadoshima J. Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. Autophagy. 2009;5:1229-31.

127 Gelpi RJ, Gao S, Zhai P, Yan L, Hong C, Danridge LM, Ge H, Maejima Y, Donato M, Yokota M, Molkentin JD, Vatner DE, Vatner SF and Sadoshima J. Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload. Am J Physiol Heart Circ Physiol. 2009;297:H1814-9. PMC2781384.

126 Fu C, Wu C, Liu T, Ago T, Zhai P, Sadoshima J and Li H. Elucidation of thioredoxin target protein networks in mouse. Mol Cell Proteomics. 2009;8:1674-87. PMC2709193.

125 Del Re DP and Sadoshima J. Optimizing cell-based therapy for cardiac regeneration. Circulation. 2009;120:831-4.

124 Cho J, Rameshwar P and Sadoshima J. Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells. J Biol Chem. 2009;284:36647-36658. PMC2794779.

123 Bellis A, Castaldo D, Trimarco V, Monti MG, Chivasso P, Sadoshima J, Trimarco B and Morisco C. Cross-talk between PKA and Akt protects endothelial cells from apoptosis in the late ischemic preconditioning. Arterioscler Thromb Vasc Biol. 2009;29:1207-12.

122 Zhai P and Sadoshima J. Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia/reperfusion. Circ Res. 2008;103:910-3. PMC2730891.

121 Shen YT, Depre C, Yan L, Park JY, Tian B, Jain K, Chen L, Zhang Y, Kudej RK, Zhao X, Sadoshima J, Vatner DE and Vatner SF. Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation. 2008;118:1961-9. PMC2634862.

120 Sadoshima J. The role of autophagy during ischemia/reperfusion. Autophagy. 2008;4:402-3.

119 Ohtsubo H, Ichiki T, Imayama I, Ono H, Fukuyama K, Hashiguchi Y, Sadoshima J and Sunagawa K. Involvement of Mst1 in tumor necrosis factor-alpha-induced apoptosis of endothelial cells. Biochem Biophys Res Commun. 2008;367:474-80.

118 Morisco C, Marrone C, Galeotti J, Shao D, Vatner DE, Vatner SF and Sadoshima J. Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes. Cardiovasc Res. 2008;78:36-44. PMC3031334.

117 Miyazaki R, Ichiki T, Hashimoto T, Inanaga K, Imayama I, Sadoshima J and Sunagawa K. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2008;28:1263-9.

116 Matsui Y, Nakano N, Shao D, Gao S, Luo W, Hong C, Zhai P, Holle E, Yu X, Yabuta N, Tao W, Wagner T, Nojima H and Sadoshima J. Lats2 is a negative regulator of myocyte size in the heart. Circ Res. 2008;103:1309-18. PMC2775813.

115 Matsui Y, Kyoi S, Takagi H, Hsu CP, Hariharan N, Ago T, Vatner SF and Sadoshima J. Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy. 2008;4:409-15. PMC2708091.

114 Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto K, Takagi H, Tamamori-Adachi M, Kitajima S and Sadoshima J. Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci U S A. 2008;105:20900-5. PMC2634936.

113 Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008;4:151-75. PMC2654259.

112 Hsu CP, Odewale I, Alcendor RR and Sadoshima J. Sirt1 protects the heart from aging and stress. Biol Chem. 2008;389:221-31.

111 Fu C, Hu J, Liu T, Ago T, Sadoshima J and Li H. Quantitative analysis of redox-sensitive proteome with DIGE and ICAT. J Proteome Res. 2008;7:3789-802. PMC2577071.

110 Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, Vatner SF and Sadoshima J. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell. 2008;133:978-93.

109 Zhai P, Gao S, Holle E, Yu X, Yatani A, Wagner T and Sadoshima J. Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. J Biol Chem. 2007;282:33181-91.

108 Yan L, Vatner DE, O'Connor JP, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J and Vatner SF. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell. 2007;130:247-58.

107 Takagi H, Matsui Y and Sadoshima J. The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxid Redox Signal. 2007;9:1373-81.

106 Takagi H, Matsui Y, Hirotani S, Sakoda H, Asano T and Sadoshima J. AMPK mediates autophagy during myocardial ischemia in vivo. Autophagy. 2007;3:405-7.

105 Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y, Sadoshima J, Vatner SF and Vatner DE. Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. J Clin Invest. 2007;117:1335-43. PMC1849986.

104 Ohtsubo H, Ichiki T, Miyazaki R, Inanaga K, Imayama I, Hashiguchi Y, Sadoshima J and Sunagawa K. Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell. Arterioscler Thromb Vasc Biol. 2007;27:1549-55.

103 Odashima M, Usui S, Takagi H, Hong C, Liu J, Yokota M and Sadoshima J. Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ Res. 2007;100:1344-52.

102 Nishizawa T, Shen YT, Rossi F, Hong C, Robbins J, Ishikawa Y, Sadoshima J, Vatner DE and Vatner SF. Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha. Am J Physiol Heart Circ Physiol. 2007;292:H971-5.

101 Morisco C, Marrone C, Trimarco V, Crispo S, Monti MG, Sadoshima J and Trimarco B. Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression. Cardiovasc Res. 2007;76:453-64.

100 Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B and Sadoshima J. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res. 2007;100:914-22.

99 Hirotani S, Zhai P, Tomita H, Galeotti J, Marquez JP, Gao S, Hong C, Yatani A, Avila J and Sadoshima J. Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res. 2007;101:1164-74.

98 Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF and Sadoshima J. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res. 2007;100:1512-21.

97 Ago T and Sadoshima J. Thioredoxin1 as a negative regulator of cardiac hypertrophy. Antioxid Redox Signal. 2007;9:679-87.

96 Zhai P, Galeotti J, Liu J, Holle E, Yu X, Wagner T and Sadoshima J. An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy. Circ Res. 2006;99:528-36.

95 Zebrowski DC, Alcendor RR, Kirshenbaum LA and Sadoshima J. Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity. J Mol Cell Cardiol. 2006;40:605-18.

94 Yan L, Sadoshima J, Vatner DE and Vatner SF. Autophagy: a novel protective mechanism in chronic ischemia. Cell Cycle. 2006;5:1175-7.

93 Usui S, Yeh I, Tian B and Sadoshima J. Global changes in gene expression during cardiac hypertrophy: a new direction of cardiac signaling research. J Mol Cell Cardiol. 2006;41:219-22.

92 Sadoshima J. Redox regulation of growth and death in cardiac myocytes. Antioxid Redox Signal. 2006;8:1621-4.

91 Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA and Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006;281:21745-21754.

90 Nishizawa T, Vatner SF, Hong C, Shen YT, Hardt SE, Robbins J, Ishikawa Y, Sadoshima J and Vatner DE. Overexpressed cardiac Gsalpha in rabbits. J Mol Cell Cardiol. 2006;41:44-50.

89 Liu J, Sadoshima J, Zhai P, Hong C, Yang G, Chen W, Yan L, Wang Y, Vatner SF and Vatner DE. Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition. J Mol Cell Cardiol. 2006;41:680-8.

88 Depre C, Wang Q, Yan L, Hedhli N, Peter P, Chen L, Hong C, Hittinger L, Ghaleh B, Sadoshima J, Vatner DE, Vatner SF and Madura K. Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation. 2006;114:1821-8.

87 Chen IY, Lypowy J, Pain J, Sayed D, Grinberg S, Alcendor RR, Sadoshima J and Abdellatif M. Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha. J Biol Chem. 2006;281:19369-77.

86 Ago T, Yeh I, Yamamoto M, Schinke-Braun M, Brown JA, Tian B and Sadoshima J. Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart. Antioxid Redox Signal. 2006;8:1635-50.

85 Ago T and Sadoshima J. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res. 2006;98:294-7.

84 Ago T and Sadoshima J. Thioredoxin and ventricular remodeling. J Mol Cell Cardiol. 2006;41:762-73. PMC1852508.

83 Zhai P, Yamamoto M, Galeotti J, Liu J, Masurekar M, Thaisz J, Irie K, Holle E, Yu X, Kupershmidt S, Roden DM, Wagner T, Yatani A, Vatner DE, Vatner SF and Sadoshima J. Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. J Clin Invest. 2005;115:3045-56. PMC1265872.

82 Yan L, Vatner DE, Kim SJ, Ge H, Masurekar M, Massover WH, Yang G, Matsui Y, Sadoshima J and Vatner SF. Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A. 2005;102:13807-12. PMC1224362.

81 Ono H, Ichiki T, Ohtsubo H, Fukuyama K, Imayama I, Hashiguchi Y, Sadoshima J and Sunagawa K. Critical role of Mst1 in vascular remodeling after injury. Arterioscler Thromb Vasc Biol. 2005;25:1871-6.

80 Morisco C, Condorelli G, Trimarco V, Bellis A, Marrone C, Condorelli G, Sadoshima J and Trimarco B. Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. Circ Res. 2005;96:180-8.

79 Hirotani S and Sadoshima J. Preconditioning effects of PKCdelta. J Mol Cell Cardiol. 2005;39:719-21.

78 Hase M, Depre C, Vatner SF and Sadoshima J. H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes. Biochem J. 2005;388:475-83. PMC1138954.

77 Ding B, Abe JI, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC and Yan C. Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure. Circulation. 2005;111:2469-2476. PMC4108189.

76 Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC and Yan C. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci U S A. 2005;102:14771-6. PMC1253575.

75 Matsui Y and Sadoshima J. Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy. J Mol Cell Cardiol. 2004;37:477-81.

74 Kim TG, Chen J, Sadoshima J and Lee Y. Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol. 2004;24:10151-60. PMC529025.

73 Kawabe J, Okumura S, Lee MC, Sadoshima J and Ishikawa Y. Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2004;286:H1845-52.

72 Karoor V, Vatner SF, Takagi G, Yang G, Thaisz J, Sadoshima J and Vatner DE. Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure. J Mol Cell Cardiol. 2004;36:305-12.

71 Hardt SE, Tomita H, Katus HA and Sadoshima J. Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy. Circ Res. 2004;94:926-35.

70 Hardt SE and Sadoshima J. Negative regulators of cardiac hypertrophy. Cardiovasc Res. 2004;63:500-9.

69 Alcendor RR, Kirshenbaum LA, Imai S, Vatner SF and Sadoshima J. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res. 2004;95:971-80.

68 Yamamoto S, Yang G, Zablocki D, Liu J, Hong C, Kim SJ, Soler S, Odashima M, Thaisz J, Yehia G, Molina CA, Yatani A, Vatner DE, Vatner SF and Sadoshima J. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest. 2003;111:1463-74. PMC155047.

67 Yamamoto M, Yang G, Hong C, Liu J, Holle E, Yu X, Wagner T, Vatner SF and Sadoshima J. Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest. 2003;112:1395-406. PMC228400.

66 Tomita H, Nazmy M, Kajimoto K, Yehia G, Molina CA and Sadoshima J. Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circ Res. 2003;93:12-22.

65 Seta K and Sadoshima J. Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor. J Biol Chem. 2003;278:9019-26.

64 Okumura S, Takagi G, Kawabe J, Yang G, Lee MC, Hong C, Liu J, Vatner DE, Sadoshima J, Vatner SF and Ishikawa Y. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proc Natl Acad Sci U S A. 2003;100:9986-90. PMC187910.

63 Okumura S, Kawabe J, Yatani A, Takagi G, Lee MC, Hong C, Liu J, Takagi I, Sadoshima J, Vatner DE, Vatner SF and Ishikawa Y. Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation. Circ Res. 2003;93:364-71.

62 Morisco C, Sadoshima J, Trimarco B, Arora R, Vatner DE and Vatner SF. Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus. Am J Physiol Heart Circ Physiol. 2003;284:H1043-7.

61 Li J, Yatani A, Kim SJ, Takagi G, Irie K, Zhang Q, Karoor V, Hong C, Yang G, Sadoshima J, Depre C, Vatner DE, West MJ and Vatner SF. Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy. Cardiovasc Res. 2003;59:649-57.

60 Kim YK, Kim SJ, Yatani A, Huang Y, Castelli G, Vatner DE, Liu J, Zhang Q, Diaz G, Zieba R, Thaisz J, Drusco A, Croce C, Sadoshima J, Condorelli G and Vatner SF. Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem. 2003;278:47622-8.

59 Kim SJ, Peppas A, Hong SK, Yang G, Huang Y, Diaz G, Sadoshima J, Vatner DE and Vatner SF. Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms. Circ Res. 2003;92:1233-9.

58 Seta K and Sadoshima J. What is the unique function of SAPK3/p38gamma in cardiac myocytes? J Mol Cell Cardiol. 2002;34:597-600.

57 Seta K, Nanamori M, Modrall JG, Neubig RR and Sadoshima J. AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs. J Biol Chem. 2002;277:9268-77.

56 Sadoshima J, Montagne O, Wang Q, Yang G, Warden J, Liu J, Takagi G, Karoor V, Hong C, Johnson GL, Vatner DE and Vatner SF. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest. 2002;110:271-9. PMC151048.

55 Sadoshima J. Novel AT(1) receptor-independent functions of losartan. Circ Res. 2002;90:754-6.

54 Hardt SE and Sadoshima J. Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development. Circ Res. 2002;90:1055-63.

53 Depre C, Hase M, Gaussin V, Zajac A, Wang L, Hittinger L, Ghaleh B, Yu X, Kudej RK, Wagner T, Sadoshima J and Vatner SF. H11 kinase is a novel mediator of myocardial hypertrophy in vivo. Circ Res. 2002;91:1007-14.

52 Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu Y, Dalton N, Chung C, Latronico MV, Napoli C, Sadoshima J, Croce CM and Ross J, Jr. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A. 2002;99:12333-8. PMC129445.

51 Yang G, Meguro T, Hong C, Asai K, Takagi G, Karoor VL, Sadoshima J, Vatner DE, Bishop SP and Vatner SF. Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis. J Mol Cell Cardiol. 2001;33:1505-14.

50 Yamamoto S, Seta K, Morisco C, Vatner SF and Sadoshima J. Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes. J Mol Cell Cardiol. 2001;33:1829-48.

49 Morisco C, Zebrowski DC, Vatner DE, Vatner SF and Sadoshima J. Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. J Mol Cell Cardiol. 2001;33:561-73.

48 Morisco C, Seta K, Hardt SE, Lee Y, Vatner SF and Sadoshima J. Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes. J Biol Chem. 2001;276:28586-97.

47 Modrall JG, Nanamori M, Sadoshima J, Barnhart DC, Stanley JC and Neubig RR. ANG II type 1 receptor downregulation does not require receptor endocytosis or G protein coupling. Am J Physiol Cell Physiol. 2001;281:C801-9.

46 Sadoshima J. Cytokine actions of angiotensin II. Circ Res. 2000;86:1187-9.

45 Morisco C, Zebrowski D, Condorelli G, Tsichlis P, Vatner SF and Sadoshima J. The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes. J Biol Chem. 2000;275:14466-75.

44 Babu GJ, Lalli MJ, Sussman MA, Sadoshima J and Periasamy M. Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. J Mol Cell Cardiol. 2000;32:1447-57.

43 Aoki H, Sadoshima J and Izumo S. Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro. Nat Med. 2000;6:183-8.

42 Aoki H, Richmond M, Izumo S and Sadoshima J. Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. Biochem J. 2000;347 Pt 1:275-84. PMC1220957.

41 Yamamoto M, Okumura S, Schwencke C, Sadoshima J and Ishikawa Y. High efficiency gene transfer by multiple transfection protocol. Histochem J. 1999;31:241-3.

40 Malhotra R, Sadoshima J, Brosius FC, 3rd and Izumo S. Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro. Circ Res. 1999;85:137-46.

39 Sadoshima J. Versatility of the angiotensin II type 1 receptor. Circ Res. 1998;82:1352-5.

38 Aoki H, Izumo S and Sadoshima J. Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res. 1998;82:666-76.

37 Todisco A, Takeuchi Y, Yamada J, Sadoshima JI and Yamada T. Molecular mechanisms for somatostatin inhibition of c-fos gene expression. Am J Physiol. 1997;272:G721-6.

36 Sadoshima J and Izumo S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol. 1997;59:551-71.

35 Sadoshima J and Izumo S. Tyrosine kinases mediation of c-fos expression by cell swelling in cardiac myocytes. Heart Vessels. 1997;Suppl 12:194-7.

34 Sadoshima J, Aoki H and Izumo S. Angiotensin II and serum differentially regulate expression of cyclins, activity of cyclin-dependent kinases, and phosphorylation of retinoblastoma gene product in neonatal cardiac myocytes. Circ Res. 1997;80:228-41.

33 Sadoshima J, Qiu Z, Morgan JP and Izumo S. Tyrosine kinase activation is an immediate and essential step in hypotonic cell swelling-induced ERK activation and c-fos gene expression in cardiac myocytes. EMBO J. 1996;15:5535-46. PMC452298.

32 Sadoshima J, Malhotra R and Izumo S. The role of the cardiac renin-angiotensin system in load-induced cardiac hypertrophy. J Card Fail. 1996;2:S1-6.

31 Sadoshima J and Izumo S. Autocrine secretion of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Contrib Nephrol. 1996;118:214-21.

30 Sadoshima J and Izumo S. The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J. 1996;15:775-87. PMC450276.

29 Jahn L, Sadoshima J, Greene A, Parker C, Morgan KG and Izumo S. Conditional differentiation of heart- and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen. J Cell Sci. 1996;109 ( Pt 2):397-407.

28 Schunkert H, Sadoshima J, Cornelius T, Kagaya Y, Weinberg EO, Izumo S, Riegger G and Lorell BH. Angiotensin II-induced growth responses in isolated adult rat hearts. Evidence for load-independent induction of cardiac protein synthesis by angiotensin II. Circ Res. 1995;76:489-97.

27 Sadoshima J, Qiu Z, Morgan JP and Izumo S. Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling. Circ Res. 1995;76:1-15.

26 Sadoshima J and Izumo S. Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy. Circ Res. 1995;77:1040-52.

25 Kai H, Koyanagi S, Hirooka Y, Sugimachi M, Sadoshima J, Suzuki S and Takeshita A. Right-to-left shunt across atrial septal defect related to tricuspid regurgitation: assessment by transesophageal Doppler echocardiography. Am Heart J. 1994;127:578-84.

24 Jahn L, Sadoshima J and Izumo S. Cyclins and cyclin-dependent kinases are differentially regulated during terminal differentiation of C2C12 muscle cells. Exp Cell Res. 1994;212:297-307.

23 Sadoshima J, Xu Y, Slayter HS and Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 1993;75:977-84.

22 Sadoshima J and Izumo S. Mechanotransduction in stretch-induced hypertrophy of cardiac myocytes. J Recept Res. 1993;13:777-94.

21 Sadoshima J and Izumo S. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J. 1993;12:1681-92. PMC413382.

20 Sadoshima J and Izumo S. Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res. 1993;73:413-23.

19 Sadoshima J and Izumo S. Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circ Res. 1993;73:424-38.

18 Sadoshima J, Takahashi T, Jahn L and Izumo S. Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes. Proc Natl Acad Sci U S A. 1992;89:9905-9. PMC50242.

17 Sadoshima J, Koyanagi S, Sugimachi M, Hirooka Y and Takeshita A. Evaluation of the severity of mitral regurgitation by transesophageal Doppler flow echocardiography. Am Heart J. 1992;123:1245-51.

16 Sadoshima J, Jahn L, Takahashi T, Kulik TJ and Izumo S. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem. 1992;267:10551-60.

15 Sadoshima J and Akaike N. Kinetic properties of the caffeine-induced transient outward current in bull-frog sympathetic neurones. J Physiol. 1991;433:341-55. PMC1181374.

14 Lai CP, Koyanagi S, Sadoshima J, Takeshita A and Tokunaga K. Transesophageal echocardiographic findings of quadricuspid aortic valve. Jpn Heart J. 1991;32:731-4.

13 Sadoshima J, Oyama Y and Akaike N. Inhibition of nicotinic acetylcholine response by atropine in frog isolated sympathetic neurons. Brain Res. 1990;508:147-51.

12 Kuga T, Sadoshima J, Tomoike H, Kanaide H, Akaike N and Nakamura M. Actions of Ca2+ antagonists on two types of Ca2+ channels in rat aorta smooth muscle cells in primary culture. Circ Res. 1990;67:469-80.

11 Sadoshima J, Akaike N, Tomoike H, Kanaide H and Nakamura M. Voltage-dependent anion-selective channels in cultured smooth muscle cells of the rat aorta. Comp Biochem Physiol A Comp Physiol. 1989;92:61-3.

10 Akaike N and Sadoshima J. Caffeine affects four different ionic currents in the bull-frog sympathetic neurone. J Physiol. 1989;412:221-44. PMC1190572.

9 Akaike N, Kanaide H, Kuga T, Nakamura M, Sadoshima J and Tomoike H. Low-voltage-activated calcium current in rat aorta smooth muscle cells in primary culture. J Physiol. 1989;416:141-60. PMC1189208.

8 Sadoshima J, Tokutomi N and Akaike N. Effects of neostigmine and physostigmine on the acetylcholine receptor-ionophore complex in frog isolated sympathetic neurones. Br J Pharmacol. 1988;94:620-4. PMC1853991.

7 Sadoshima J, Akaike N, Tomoike H, Kanaide H and Nakamura M. Ca-activated K channel in cultured smooth muscle cells of rat aortic media. Am J Physiol. 1988;255:H410-8.

6 Sadoshima J, Akaike N, Kanaide H and Nakamura M. Cyclic AMP modulates Ca-activated K channel in cultured smooth muscle cells of rat aortas. Am J Physiol. 1988;255:H754-9.

5 Oyama Y, Sadoshima J, Tokutomi N and Akaike N. Some properties of inhibitory action of lidocaine on the Ca2+ current of single isolated frog sensory neurons. Brain Res. 1988;442:223-8.

4 Sadoshima J, Taira Y, Shimokawa H, Koyanagi S, Takeshita A and Nakamura M. Two cases of dilated cardiomyopathy complicated by left ventricular aneurysm. Chest. 1987;92:377-9.

3 Sadoshima J, Nakashima Y, Taira Y, Koyanagi S, Takeshita A, Tanaka K and Nakamura M. A case of primary dissecting aneurysm of the coronary artery. Jpn Heart J. 1987;28:799-804.

2 Inoue M, Sadoshima J and Akaike N. Different actions of intracellular free calcium on resting and GABA-gated chloride conductances. Brain Res. 1987;404:301-3.

1 Tsuji H, Murai K, Sadoshima J, Nagasawa K, Kajiwara E, Kobayashi K, Akagi K, Fujishima M, Sumiyoshi K and Beppu K. [An autopsied case of Budd-Chiari syndrome associated with multiple myeloma and amyloidosis]. Nihon Shokakibyo Gakkai Zasshi. 1986;83:688-92.