Welcome to
the Sadoshima Lab
AHA 2014 Scientific Sessions News
November 15-19
Lab members presented following titles at the conference:
Shinichi Oka

Shouji Matsushima


Yoshiyuki Ikeda

Toshiro Saito

Yoshiyuki Ikeda

Paul Ammann


Michinari Nakamura


Yasuhiro Maejima

Junichi Sadoshima

Narayani Nagarajan

Sebastiano Sciarretta


Junichi Sadoshima


Peiyong Zhai

Akihiro Shirakabe

Junichi Sadoshima
"PPARalpha/Sirt1 Heterodimer Suppresses Fatty Acid Oxidation Genes in the Heart"

Melvin L. Marcus Young Investigator Award Finalist
"Fyn is a Sensor and Regulator of Nox4-derived ROS in the heart"

"Mitochoondrial Fission Plays a Crucial Role in Cardiomyocyte Adaptation to Energy StressviaMitophagy"

"Ulk1 Plays a Crucial Role in Mitochondrial Autophagy in Cardioyocytes"

"Prolonged Inhibition of Mitochondrial Fission Enhances Myocardial Injury in Respose to Ischemia/Reperfusion"

"The Retinoblastoma Proteinis Inactivated in Response to Cardiac Pressure Overload and Regulates Apoptosis and Autophagy
in Cardiomyocytes"

"Glycogen Synthase Kinase-3alpha Plays a Critical Role in the Development of Cardiac Dysfunction during Obesity and Insulin
Resistance through Phosphorylation of Peroxisome Proliferator-Activated Receptor alpha"

"Mst1 Plays a Protective Role in Respoonse to Ischemia in the Heart by Promoting C/EBP-beta Activation"

"Physiological and Pathological Functions of Nox4 in the Heart"

"Trx1 Promotes Trans-Nitorylation of Cellular Proteins to Stimulate Autophagy and Cell Survival"

"Activation of PKR-Like Endophasmic Reticulum Kinase is Required for Autophagy Stimulation and Cardiomyocyte Survival
during Acute Myocardial Ischemia"

Thomas Smith Memorial Lecture
"Regulation of Myocardial Growth and Death by the HIPPO Signaling Pathway"

"Constitutively Active GSK-3beta Attenuates Cardiac Aging through Ulk1-Dependent Stimulation of Autophagy"

"Drp1 Accumulates in Mitochondria and Plays a Protective Role in the Heart in Response to Pressure Overload"

"NOX4 Activation by Energy Stress in the ER of Cardiac Myocytes"
Dr. Sadoshima received the
John Foerster Distiguished
Lecture Award
from the
Institute of Cardiovasucular
Sciences of University of
Manitoba and St. Boniface
Hospital Foundation,
Canada.